Kounis syndrome secondary to heparin in a newborn with hypoplastic left heart

Autores/as

  • Elena Ramírez
  • Miguel Gonzalez

Resumen

Kounis syndrome (KS) is an acute coronary syndrome (ACS) described in relationship with drugs or stents. KS was suspected in a full-term newborn who underwent a Rashkind-atrioseptostomy and stenting that periodically developed episodes of ACS. Skin test with nickel and titanium were performed being negatives. Basophil activation (BAT) and lymphocyte transformation (LTT) tests were performed for the suspected drugs. Non-responder basophils in BAT and a positive LTT for heparin were found. A new dose of heparin was administered by error, after which a new ACS was developed. We described the first report of KS by drug in a newborn.

Authors: Paloma López Ortego1, Javier Queiruga Parada2, Luz Yadira Bravo Gallego3, Carmen Gómez Traseira4, Viviana Arreo5, Juvenal Rey6, Amelia Rodríguez Mariblanca2, Enrique Seco Meseguer2, Miguel González-Muñoz4*, Elena Ramírez2*

1Pediatric Department, La Paz-Cantoblanco-Carlos III University Hospital, Madrid, España. 2Clinical Pharmacology Department, La Paz-Cantoblanco-Carlos III University Hospital, IdiPaz, Facultad de Medicina UAM, Madrid, España. 3Immunology Department, La Paz-Cantoblanco-Carlos III University Hospital, IdiPaz, Madrid, España. 4Alergy Department, La Paz-Cantoblanco-Carlos III University Hospital, IdiPaz, Madrid, España. 5Pediatric Cardiology, La Paz-Cantoblanco-Carlos III University Hospital, IdiPaz, Madrid, España. 6Pediatric cardiovascular Surgery, La Paz-Cantoblanco-Carlos III University Hospital, IdiPaz, Madrid, España.

 

Descargas

Publicado

2023-04-19

Número

Vol. 1 Núm. 0015 (2020): Protocol: Kounis syndrome secondary to heparin in a newborn with hypoplastic left heart.

Sección

Articles

Licencia

Derechos de autor 2023 Elena Ramírez, Miguel Gonzalez

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).