DRESS en paciente con toxoplasmosis y sÃndrome antisintetasa
Resumen
Se define como sÃndrome de DRESS a una reacción cutánea grave caracterizada por la aparición de erupción cutánea, adenopatÃas, fiebre, eosinofilia, leucocitosis y/o afectación orgánica a las 2-6 semanas de iniciar tratamiento con un fármaco.1,2 Con mayor frecuencia, los fármacos implicados son anticonvulsivantes, sulfamidas, alopurinol y antibióticos betalactámicos. En el caso de las sulfamidas, la incidencia de reacciones cutáneas en general es del orden de 3-5 casos de cada 100 personas expuestas.3 Presentamos un caso de sÃndrome de DRESS durante tratamiento con Sulfadiazina/Pirimetamina con reactivación posterior con Sulfametoxazol/Trimetoprim y exantema con Clindamicina asociada a Pirimetamina. Confirmada hipersensibilidad retardada a sulfadiazina, sulfametoxazol y Pirimetamina mediante TTL (test de transformación linfocitaria).
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